She earned a master's degree and a Ph.D. in organic chemistry at Tulane University,[2] where she was an associate member of the Sigma Xi honor society.
[4] The couple moved to the United States together in 1946, and had two sons while Marguerite Chang was a graduate student at Tulane University.
[2] She was named as an inventor on several patents, assigned to the United States government between 1976 and 1986, for processes, production methods and chemical compositions.
[6] Chang's scientific publications included "The Identification of C32H20N4O8, a Product from Acetophenone and Nitric Acid" (Journal of the American Chemical Society 1960, with Joseph H. Boyer), and "Bis(cyclopropanecarbonyl)furoxan" (Journal of Organic Chemistry 1968, with James U. Lowe Jr.).
[7] Chang is included in Conversations 760-009 and 871-009 of the White House Tapes, in the Oval Office for a photo sessions with President Richard Nixon and others in August 1972 and March 1973.