[5][6] As a record producer with a blend of house music, amapiano and afropop, he has worked with and has received production credits from several notable artists, including Wizkid, Sizwe Alakine, Kwesta, Uhuru, Drake, Black Coffee, Major Lazer, Runtown, C4 Pedro, TRESOR, Kabza De Small, Era Istrefi, Mpura, Young Stunna and Killer Kau.
In 2011, she founded Protocinema, a mission-driven art organization that creates opportunities for emerging and established artists from all regions, in cities where their work has yet to have much exposure.
[4] In 2014, the gallery Artspace, in Sydney, Australia, invited Spirito as a guest curator to represent a range of Turkish independent, not-for-profit and museum sectors.
Convening the likes of Marina Abramovic, Arthur Jafa, Sheikha Hoor al Qasimi, Glenn Ligon and Claudia Rankin, Spirito felt that, "the most important thing is to have different points of view.
From 2015 through 2017, Spirito served as director and curator of 'Alt' ('below' in Turkish), an art space opened in January 2016 on the site of the historic Bomonti Beer Factory in Istanbul's Şişli district.
[9] In 2018, Spirito curated a program called Nature of Justice, which was a visual arts interpretation of The Birds,[10] the play by Aristophanes, produced in partnership with St. Ann's Warehouse, which ran May 2–13, 2018.
[14] The resulting work was Rossella Biscotti's The City, a five-channel video installation visiting the 9,000 year old neolithic archeological site Çatalhöyük, which was presented in a subterranean space near Taksim Square from September 29-October 27, 2018.