In 1989 Cuffaro headed the program 'Il filo d'Arianna' on Rai 3,[9] which deals with inquiries from abroad.

An investigative journalist, she has been to war zones and has produced numerous reports from Asia, Africa and South America.

[11] Since June 2006 she has been a regular guest on the entertainment program Matinee on Rai2 and led by Max Giusti and Sabrina Nobile.

In 2011, during a service of the TG3 in Tunis, she was attacked with her cameraman Claudio Rubino, but still managed to return to the hotel without serious injury.

[15] In 2013 she opened the twelfth edition of Sabato del Villaggio, in the elegant surroundings of the Theater Umberto di Lamezia Terme.