María Enríquez de Luna (1474 – 1539) was the wife of Juan (Giovanni) Borgia, second Duke of Gandía.

The younger Juan was the father of Saint Francis Borgia.

In personality, María was very intelligent, devout, financially shrewd, and devoted to her husband and children, in contrast to her husband, who was regarded by many as a womanizer, a gambler, a drunkard, and an incompetent general.

Sometime after the end of Pope Alexander VI's papacy, María, along with her aunt Isabella of Castile, tried to press murder charges against her brother-in-law, Cesare Borgia for the alleged murder of her husband Juan.

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