Sansone was born in Erie, Pennsylvania, and started in the television business as an 11-year-old sports reporter for WJET-TV in her home town.

[citation needed] Prior to graduating from Syracuse, she was hired as a VJ for MTVU, where she hosted and produced shows from colleges and spring break locations around the world.

Sansone then spent several years co-hosting Los Angeles' morning news show, Good Day LA on Fox 11 alongside Steve Edwards.

At Fox 11, she anchored 20 hours of live television per week, which included interviewing Hollywood stars and covering breaking news.

Sansone lives in Boston, Massachusetts, with her husband, Josh, their children, Grace and Benjamin, and their dog, Ralphie.