In 1777, Mariam married Prince David Tsitsishvili (1749–1792), a scion of the medieval house of Panaskerteli and governor (mouravi) of the royal capital of Tbilisi.
The couple had 7 children:[1] After the annexation of the Georgian kingdom by the Russian Empire in 1801, the widowed princess Mariam lived a reclusive life.
[2] Being one of the few members of the Georgian royal family to avoid deportation to Russia proper, she retired to her rural estate at Kareli, part of her dowry.
In 1803, the Russian authorities contemplated to give her the village of Didi Shulaveri in permanent and hereditary possession, but this was eventually ruled to be unfeasible.
Her works, such as her best poem, "Alas, that the sweetness of time should turn better" (ჰოი, დამწარდეს დროთა ტკბილობა), are of early Romantic flavor, inspired by the loss of the native kingdom and family.