She researches mechanisms of immune dysregulation, organ damage, and premature vascular disease in systemic autoimmunity.

Kaplan is chief of the systemic autoimmunity branch at the National Institute of Arthritis and Musculoskeletal and Skin Diseases.

[1] In 2013, Kaplan joined the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) as chief of the systemic autoimmunity branch.

[1] Kaplan's research has focused on identifying mechanisms of immune dysregulation, organ damage, and premature vascular disease in systemic autoimmunity.

[1] She investigates how innate immunity (in particular, type I interferons and myeloid cells) promote autoimmune responses and end-organ damage in systemic lupus erythematosus, rheumatoid arthritis, and other systemic autoimmune diseases.