[citation needed] In 1993, Mayberry became an ensemble member of the Steppenwolf Theatre Company in Chicago, Illinois.

While at Steppenwolf, she was nominated for a Joseph Jefferson Award for Actress in a Supporting Role in a Play for Time of My Life, and again for Actress in a Principal Role in a Play for Hysteria, directed by John Malkovich.

[citation needed] In 2006, Mayberry married fellow actor Scott Jaeck, with whom she shared the stage in the Broadway run of Tracy Letts' Tony Award- and Pulitzer Prize-winning play August: Osage County.

[2] On August 1, 2017, aged 52, Mayberry died of ovarian cancer at her sister (Melissa Hollander)'s home in Simsbury, Connecticut.

At the time, Mayberry lived in New York with her husband of 11 years, actor Scott Jaeck.