Born in Tres Sargentos, Buenos Aires Province, Pavone left his childhood club Boca Juniors at the age of 14, and went on to feature for Estudiantes de La Plata in the Argentine Primera División during seven years (11 comprising youth).

[3] Pavone was selected by sports newspaper Olé as the best player in the 2006 Apertura tournament, where he helped Estudiantes win the championship playing 17 games and scoring 11 goals.

[8] In his first two seasons he failed to impress, but had a good run from November 2007–January 2008, when he netted six goals in five matches, including braces against Real Zaragoza (a 2–1 win, as a late substitute)[9] and UD Almería (a 3–1 victory).

[12] On 23 July 2010, Club Atlético River Plate and Betis arranged a one-year loan deal for Pavone, who returned to his country after three years.

On 26 June 2011, after a 0–2 away loss, he scored in the first minutes of the game but also had a penalty saved by Juan Carlos Olave, in an eventual 1–3 aggregate defeat which sent the historical Buenos Aires team to the second level for the first time in its history.

In June 2012, Pavone joined Cruz Azul in the Liga MX, helping to the conquest of two major titles in two years, including the 2013–14 edition of the CONCACAF Champions League where he scored his team's only goal in the finals and was awarded the Golden Ball.