She became an entrepreneur in the field of debt collection with the "Euro Service Group" of her husband at the time, Antonio Persici, with whom she has a son named Lorenzo.

On 20 May 2014, she replaced Sandro Bondi as Forza Italia special commissioner with the task of cutting costs and signing nominations.

Together with Giovanni Toti, Francesca Pascale, Alessia Ardesi and Deborah Bergamini, Rossi formed Berlusconi's so-called "magic circle".

On June 29, 2016, Rossi resigned as party commissioner being replaced by Alfredo Messina and at the same time she was appointed Treasurer of the Forza Italia Group in the Senate.

On 24 June 2013, as part of the trial for extortion and child prostitution against Silvio Berlusconi, the minutes of Rossi's deposition were transmitted to the prosecution to assess whether or not the conditions existed for her to be investigated for perjury.