From 2005 to 2013, she played professionally for several teams around the world including FC Barcelona, UE L'Estartit, San Diego Sunwaves, Chicago Red Stars, and UAEH Panteras.

They called her Mario and only found out that she was a girl when her picture appeared in the newspaper after she made it on the sub-national women's team.

[13] In 1997, Domínguez joined a women's team called Inter and was forced to have a full body inspection by a female Mexico league official to validate her sex due to her short hair and ability to "play like a man.

[6][13] With the absence of a women's professional league in Mexico, Domínguez immigrated to the United States to play with the Kansas City Mystics in 2002 and further her development as a footballer.

During her first and only season with the Mystics, she led the league with 17 goals and 12 assists while helping the team clinch the Midwest Division title.

[20] In December 2004, Domínguez made international headlines when she signed a two-year contract for second division men's team, Atlético Celaya, in Guanajuato, Mexico.

"[6] Beginning in early 2005, Domínguez played for FC Barcelona in Spain's top division league, Superliga Femenina.

Her debut for FC Barcelona occurred on 30 January 2005 during a match against Torrejón where she scored a hat-trick and helped the squad win 5–3.

[28] In the 2007 summer season, Domínguez fulfilled a prior obligation to play for San Diego Sunwaves in the American W-League.

[33] Difficulties with her visa and commitments with the Mexico national team eventually reduced Domínguez's playing time with UE L'Estartit.

[6][24] She scored Mexico's only goal in the tournament during a 7–1 loss to Brazil at Giants Stadium in East Rutherford, New Jersey.

[44][45] On 5 November 2010, Domínguez scored the opening goal in Mexico's 2–1 upset victory over the United States during the semifinals of the CONCACAF Women's World Cup Qualifying Tournament.

During the team's second group stage match against Trinidad and Tobago, she scored Mexico's only goal on a penalty kick in the 42nd second.

[47] After Mexico won their third group stage match 1–0 against Colombia, the team advanced to the semi-finals where they were defeated 1–0 by Brazil.

[48] The same year, Domínguez led CONCACAF's second-place team to play in the 2011 FIFA Women's World Cup in Germany.

[49] The squad's opening group stage match resulted in a 1–1 draw against England at Volkswagen-Arena in Wolfsburg in front of 18,702 spectators.

[50] During its second group stage match on 1 July, Mexico was defeated 4–0 by the eventual gold medal-winning team, Japan.

On 21 July 2022, Dominguez and her coaching staff were suspended and separated from the team by the FMF due to a matter that required an internal investigation to be open.