[4] Santiago was born in Los Reyes la Paz, part of the Greater Mexico City area.

She started playing for the women's team of Club Santos Laguna in the Super Liga Femenil de Fútbol in October 2010.

In February 2016, Santiago signed for Icelandic top division team Þór Akureyri.

[9] Earlier in the year, she had been part of the Mexico U17 team that reached the final of the CONCACAF U17 Championships in March, losing 1–0 to Canada.

[10] Two years previously, she had been the youngest player at the 2008 U20 World Cup in Chile, featuring in the Mexico squad less than two months after her fourteenth birthday.