Born in the city of San Marino, Reffi studied art at the Accademia di Belle Arti di Bologna, where her instructors included Giorgio Morandi, Virgilio Guidi, and Luciano Minguzzi.
She was also one of the first three women to be elected to the Grand and General Council[2] in 1974, alongside Clara Boscaglia and Fausta Morganti.
[4] She declined, however, to take her seat, deferring instead to her husband, Giordano Bruno Reffi, who had been elected on the same list.
[6] Reffi was active in Italian cultural circles throughout her life, and counted among her friends the artist Emilio Vedova.
[2] Her 1981 monument in stone to the luthier Marino Capicchioni may be seen in the Old City of San Marino, where it is displayed as part of the Open Air Museum; other works on view in the town include History of Science (1963, cement)[7] and the undated Testimony 1 and Testimony 2,[8] both in stone.