He worked in his field at the Centro Regional Litoral and in the water departments of the provincial governments of Entre Ríos, Santa Fe, Chaco, Misiones and Río Negro.

On 22 February 2000 the University Assembly elected him rector, in order to complete the term of Hugo Storero (who had resigned to become a National Deputy).

[4] Barletta ran for the office of Mayor of Santa Fe City on the election of 2 September 2007, representing the Progressive, Civic and Social Front (the same coalition which took the Socialist Hermes Binner to the governor's seat).

[5] Among his first government measures, Barletta announced the start of a permanent internal audit of the municipality's finances, and declared a "hydrical emergency", to deal swiftly with the vulnerable state of the city facing large amounts of rainfall.

Days after completing his term as Mayor of Santa Fe, Barletta was elected President of the National Committee of the Radical Civic Union (UCR) in December 2011 as a consensus candidate.