Sergio Edgardo Acevedo (born 1 May 1956) is an Argentine politician, formerly a provincial governor of Santa Cruz Province and secretary in the national government.

He was confirmed by President Néstor Kirchner, but later resigned to take up the post of Governor of Santa Cruz Province, swapping positions with Héctor Icazuriaga.

However, his resignation came after clashes with the national government and amid controversy over police brutality in repressing the Las Heras riot and a corruption scandal involving the family of President Kirchner.

Members of his family held senior positions and Acevedo retained Carlos Kirchner as his provincial minister of works.

It was widely speculated at the time that Acevedo resigned due to Presidential interference, in particular with oil and privatisation policy,[3] and he has subsequently become a vocal, if equivocal, opponent of his former mentor and patron.