A powerful winger or striker, he played for Boca Juniors, Racing Club de Avellaneda and Huracán in Argentina, Genoa in Italy and Millonarios in Colombia.

Nicknamed El Atómico (The Atomic One), he started playing in the youth division of Boca Juniors to debut in first division on 8 June 1941 in the victory against Independiente, and scoring his first goal a week later against Huracán.

He moved to Italy where he became "Il Matadore" (The Killer), but returned to Argentina four seasons later.

After winning the 1951 league with Racing and playing one season for Huracán, he returned to Boca to retire a year later.

In 1963 former Boca Juniors player Mario Boyé and former San Lorenzo de Almagro player René Pontoni, brothers-in-law who had both been members of Argentine national teams, set up a pizzeria in Belgrano, Buenos Aires, La Guitarrita , which expanded into a chain, still run by Pontoni's grandson as of 2024[update].