He was inspired to create his own science-based medicine show after listening to the Slacker Astronomy podcast.

[17] He writes posts for a Medscape blog called Rubor, Dolor, Calor, Tumor.

[22] Crislip was the president and co-founder of the Society for Science-Based Medicine (SfSBM), a nonprofit education and advocacy group.

[26] Several organizations that promote science and skepticism have invited Crislip lecture on alternative medicine and the anti-vaccine movement.

[27] In June 2010 he gave a talk called "The Vaccine Pseudo-Controversy" for the Center for Inquiry Portland.

[28] In November 2013 he spoke at a meeting of Oregonians for Science and Reason on the topic of "Supplement, Complementary and Alternative Medicine Myths.

"[31][32][33] Crislip has been on the Top Docs list published by Portland Monthly magazine several times,[21] most recently in 2014.