Mark Christopher Lowe (born June 7, 1983) is an American former professional baseball pitcher.

He made his Major League debut for the Seattle Mariners on July 7, 2006, in relief against the Detroit Tigers, loading the bases before striking out the side.

[1] Lowe was placed on 60-Day disabled list on April 1 and began a rehabilitation assignment on July 3 with the Triple-A Tacoma Rainiers.

On July 9, 2010, Lowe was traded to the Texas Rangers with Cliff Lee for Justin Smoak and prospects Blake Beavan, Josh Lueke and Matt Lawson.

He made his debut for the Rangers on September 29, 2010, against Seattle, coming back from injury to throw a scoreless inning against his former team.

He was on the mound when David Freese hit the walk off home run to end Game 6 of the 2011 World Series.

On February 8, 2013, he signed a minor league contract with the Los Angeles Dodgers that included an invitation to spring training.

[7] On December 18, 2014, the Seattle Mariners signed Lowe to a minor league contract with an invitation to spring training.

On July 31, 2015, Lowe was traded to the Toronto Blue Jays for Rob Rasmussen, Jake Brentz, and Nick Wells.

His combined totals for 2015 (with Seattle and Toronto) were: 55 innings, 1–3 record, 13 games finished, and a 1.96 ERA.

On July 24, 2017, Lowe was traded to the Chicago White Sox, along with fellow veteran pitcher Jean Machi, and assigned to the Triple–A Charlotte Knights.

[12] On April 15, 2019, Lowe signed with the Sugar Land Skeeters of the Atlantic League of Professional Baseball.

Lowe played High School Baseball at Fort Bend Baptist Academy in Sugar Land, Texas.