Mark Edison Saccomanno (born April 30, 1980) is an American former professional baseball first baseman.

At 18, was named Second-Team All-District 16-5A as a shortstop and received the National Scholar Athlete Award.

Saccomanno was called up to the majors by the Houston Astros on September 8, 2008, and hit a home run on the first pitch of his first major league at-bat, pinch hit for pitcher Alberto Árias, against Pirates' pitcher Ian Snell.

A free agent at the end of the season, he re-signed with the Astros on January 5, 2009 to a minor league deal with an invitation to Spring training as a non-roster player.

This biographical article relating to an American baseball first baseman is a stub.