[1][2][3] Galante was selected as the 833rd and final pick of the 1966 Major League Baseball draft by the New York Yankees.

He played in the Yankees system from 1966 to 1971, and spent the 1972 and 1973 seasons with the Evansville Triplets, the AAA affiliate of the Milwaukee Brewers.

He was a Houston Astros coach from 1985 to 2001 with the exception of 1997, when he worked in the club's front office and then stepped in as manager of the AAA New Orleans Zephyrs when Steve Swisher resigned a few days into the season.

Craig Biggio credited Galante with assisting him in transitioning from a Catcher to a Second Baseman, a move that extended his career to 20 years in the Majors.

In his Hall of Fame address, he asked Galante to stand up for special recognition, saying, "I wouldn't be here without him.