[6] In the Himalayas, Twight attempted more routes than he succeeded on, being turned away by the South Pillar of Nuptse with Jeff Lowe (twice), and shut down 1,200 feet (370 m) below the summit of Nanga Parbat when a storm forced retreat down the Rupal Face (accompanied by Barry Blanchard, Kevin Doyle and Ward Robinson).
[7][8] Other notable Himalayan climbs include the first ascent of the northwest face of Kangtega with Alison Hargreaves, Tom Frost and Jeff Lowe.
In 1994, he and Scott Backes climbed "Deprivation" on Mount Hunter in 72 hours roundtrip, which halved the previous fastest ascent of the North Buttress.
[11] Twight's participation in this style of climbing culminated with the 60-hour ascent of the Slovak Direct on the south face of Denali in June 2000 with Backes and Steve House.
"[18] Mark Twight was the founder of Gym Jones,[19][20] where he trained athletes (including MMA fighters, NFL players and professional cyclists), military personnel, actors and others.
He also consults as the technical director of Mountain Mobility Group, LLC, which provides "cold weather, high altitude, and fitness training, as well as R&D for the Department of Defense.
"[21] He was hired as the subject matter expert during the development of the Protective Combat Uniform (PCU) currently issued to special operations personnel.
[38] He has competed in a wide range of races, from omniums and hill climbs to the grueling LOTOJA (Logan to Jackson) Classic[39] and has also written essays about cycling on his own and other websites.