A member of the Republican Party, Uyeda has served as a Commissioner of the U.S. Securities and Exchange Commission (SEC) since June 30, 2022.

Uyeda stated his grandfather and mother were interned due to Executive Order 9066, which forced him to rebuild his business.

He has also worked on detail as a Republican staffer for the United States Senate Committee on Banking, Housing, and Urban Affairs.

[8][9] In April 2022, President Joe Biden nominated Uyeda to fill a vacant seat on the SEC left formerly held by Elad Roisman.

[10] His nomination was supported by Senator Pat Toomey (R-PA), who signed a letter of recommendation in his favor.

[15] On October 19, 2023, a hearing on his nomination was held before the Senate Banking, Housing, and Urban Affairs Committee.