The assumed course of study follows the Smart Core curriculum developed by the Arkansas Department of Education (ADE), which requires students to complete at least 22 units to graduate.

Students complete regular (core and career focus) courses and exams and may select Advanced Placement coursework and exams that provide an opportunity for college credit.

For 2012-14, the Marked Tree Indians compete in the 2A Region 3 (Football) Conference under the administration of the Arkansas Activities Association.

The Indians participate in a variety of Interscholastic activities including football, golf (boys/girls), basketball (boys/girls), baseball, softball, and track (boys/girls).

[4] Golf Men's Basketball The marked tree high school band plays at football games, seasonal concerts, and parades.