[11] In Week 8 of the 2022 NFL season, Tuipulotu recorded the first sack of his career, tackling Pittsburgh Steelers quarterback Kenny Pickett in a 13–35 win.
[12] In Week 10 of the 2022 season, Tuipulotu recorded the first fumble recovery of his career in a game against the Washington Commanders.
[14][15] Without Tuipulotu, the Eagles reached Super Bowl LVII but lost 38–35 to the Kansas City Chiefs.
[17] On August 31, 2024, Tuipulotu was signed to the Kansas City Chiefs practice squad, then promoted to the active roster a week later.
He is also the cousin of former USC and current San Francisco 49ers defensive back Talanoa Hufanga.