He played college football for the Mississippi State Bulldogs and was selected by the Chiefs in the second round of the 2016 NFL draft.

[11] While running the 40-yard dash, Jones had a wardrobe malfunction that exposed his genitalia before falling to the ground to fix the issue.

[16] He entered training camp competing with Jaye Howard, Allen Bailey, Nick Williams, and Jimmy Staten to be the starting defensive end.

Jones was named the backup left defensive end, behind Jaye Howard, to begin the regular season.

[17] Jones made his professional regular season debut in the Chiefs' season-opening 33–27 victory over the San Diego Chargers.

On October 18, 2016, he was named the starting right defensive end after Allen Bailey was placed on injured-reserve with a shoulder injury.

[19] On October 23, 2016, Jones earned his first career start and recorded two solo tackles in a 27–21 win against the New Orleans Saints.

[20] The next game, he made a solo tackle and his first career sack on Andrew Luck in a 30–14 victory over the Indianapolis Colts.

[21] In a Week 10 matchup with the Carolina Panthers, Jones made three solo tackles and sacked Cam Newton in a 20–17 win.

[28] Overall, he finished the 2017 season with 6.5 sacks, 32 total tackles, one interception, seven passes defensed, and four forced fumbles with five starts and 16 appearances.

[32] He finished the season third in the league with 15.5 sacks, which led the Chiefs, along with 40 combined tackles, five passes defensed, two forced fumbles, and an interception.

[48] The Chiefs went on to reach Super Bowl LV, but failed to defend their championship after losing to the Tampa Bay Buccaneers 31–9.

[57] In Super Bowl LVII, Jones recorded three tackles in the Chiefs 38–35 win over the Philadelphia Eagles.

[67] Most importantly, on the first drive of overtime, Jones generated a critical third down pressure in the red zone to prevent a San Francisco third down conversion and touchdown.

San Francisco had to settle for a field goal as a result, and Kansas City scored a touchdown on the ensuing drive to win the game and the championship.

[69] A free agent following the 2023 season, Jones signed a five-year, $158.75 million deal to return to the Chiefs on March 11, 2024.

The contract contains $101 million in guarantees and makes him the highest-paid defensive tackle in NFL history in average annual value.