She made five complete voyages for the British East India Company (EIC) before she was lost in 1813 on her sixth.

Marquis Wellesley reached Madras on 12 July, Penang on 27 August, and Malacca on 24 September.

Homeward bound, she crossed the Second Bar, reached St Helena on 15 April, and arrived back at the Downs on 12 June.

[1] Captain Charles Le Blanc sailed from Portsmouth on 20 March 1804, bound for Madras, and Bengal.

[1] The EIC decided a cartel to transfer French prisoners to Isle de France (Mauritius).

She reached Point de Galle on 7 March and St Helena on 11 June; she arrived at the Downs on 14 August.

She stopped at Vizagapatam on 31 December, Madras, on 13 January 1810, and Colombo on 3 February She reached St Helena on 3 May and arrived at the Downs on 6 July.

[1] Either on her way to Madras or after, Marquis Wellesley sustained damages that led Captain Le Blanc to sail to Bombay to effect repairs.

[1] On 16 April 1813 Marquis Wellesley, Le Blanc, master, struck a rock in Bombay Harbour and became a total loss.

[1] As she was coming out of dock at Bombay after having received repairs she struck a rock near the pier head and foundered.