Robert Pittman, chairman and CEO of iHeartMedia Inc., stated, "Hollywood Hamilton is one of the most loved, respected and recognized voices and names in radio, his unparalleled ability to connect with both listeners and music's biggest artists is a true representation of what makes radio the most powerful medium in the U.S."[2] Hamilton was born and raised in both Las Vegas and Reno, Nevada.

Both his parents were in show business; his father, Al, was the entertainment director for major Nevada hotels and casinos, and also a comedian who performed in those establishments.

Hamilton's mother, April Ames, was a singer for Harry James, Sam Donahue, Buddy Rich, and others during the "big band" era.

[4] After weeks of complaints from local commercial radio stations, the Federal Communications Commission issued a formal cease and desist.

[5] In 1990 actor Christian Slater studied the role of playing a DJ for the motion picture Pump Up the Volume under the tutelage of then friend Hamilton.

In 1996, Clear Channel convinced Hamilton to relocate back to New York City to host a show for their WKTU evening slot.

After spending only a year broadcasting in his hometown, Hamilton decided to hit the road hoping to achieve the big time one day.

In 1983 while broadcasting one night, his big break came when a then famous radio executive Scott Shannon was flying commercially over Long Branch and heard Sean on the air.

Upon Shannon's arrival at his destination Sean was immediately offered a job to be part of creating and premiering what is now the largest and most influential radio station in the world today, New York's WHTZ/Z100.

He was Clear Channel's only "music" radio personality to have an afternoon show broadcasting simultaneously in both New York and Los Angeles, Monday through Friday.

[10] After the show became a huge hit in New York Hamilton signed the rights over to the Westwood One Radio Network for an undisclosed financial amount, stopped hosting it and moved to Los Angeles to work for KIIS-FM.

[11] The four-hour show was called "Hangin' with Hollywood" and featured interviews with music, television and motion picture celebrities on the Tomorrowland main stage.

This live radio show quickly became a Disney attraction for tourists who could watch celebrities being interviewed and participate by being "guest DJs", introducing the music on the air.

[17] Hamilton has been the spokesman and spokesmodel for companies including Sprint Nextel, Drakkar Cologne, Doritos, M&M's, Levi Strauss & Co., Pepsi and 5-Hour Energy.

Shooting began in Ibiza, Spain July 5 and then continuing on to Amsterdam, Bucharest, Mamaia, Athens, Mykonos, Prague, Berlin, Hamburg, Budapest, Croatia, Belgrade, Paris finishing up in Rome.

On July 21, 2013, Hamilton alongside his wife Marina completed a six-day, 350-mile bike ride from Washington, D.C., to Pittsburgh to raise funds and awareness for Wounded Warrior Project, a non-profit organization dedicated to helping thousands of injured soldiers returning home from current conflicts and providing assistance to their families.

Covering approximately 70 miles a day, the duo video blogged the entire journey on the donation site GoFundMe where they met their goal of $10,000.