[2] Notable directors from the series include Marvel Comics collaborator and actor Paul Scheer[14] and Community's Gillian Jacobs, who also acted in the third reboot of The Twilight Zone and Mike McMahan's Rick and Morty.

[17] Caroline Framke of Variety found the stories provided by the anthology documentary fascinating, writing, "Marvel's 616" might not convince someone with little to no interest in comics of their potential virtue, but it's not trying to.

Instead, it uses the vast records at its disposal to build a living history to show how, and why, Marvel has become such an unstoppable behemoth, doubters be damned.

positively, noting that the episode was "truly special" because it highlighted five New York Comic Con Marvel costume cosplayers, including StrongInCostume and ZiaCosplay.

Club gave the series an "A−" rating and stated that the show avoids mythologizing Marvel and succeeds to approach its universe, saying, "You might not walk away with a grand cohesive understanding of how Marvel has impacted the lives of its fans and employees, but you will come away with a very specific understanding of how it has impacted specific fans and employees in related and heartwarming ways.

"[21] Richard Trenholm of CNET pointed out that certain fans of Marvel questioned the company's decision to feature Dan Slott in the seventh episode, titled "The Marvel Method", as it depicts him writing very slowly and putting those who work around him in dire situations by doing this, and some readers wondered if Slott was even working, or just slacking off.