Mohsen made his debut with Egypt on 3 September 2011 against Sierra Leone in a 2012 Africa Cup of Nations qualifier, where he also scored his first international goal.

He earned a spot on Hany Ramzy's Egypt U-23 squad, who were trying to qualify for the 2011 All-Africa Games and the 2012 Summer Olympics, after finishing with a good 2010–11 season with 4 goals.

In early June 2012, Mohsen's Petrojet coach told the media that “He will move to Europe and the board is studying offers from a number of big clubs,” and continued on to say “Marwan Mohsen is one of the best forwards in Egypt and his place is in the big European leagues.” Interest from Egyptian giants Al Ahly and Zamalek as well as European teams grew exponentially as he succeeded with the Egypt U-23 team leading up to the 2012 Summer Olympics.

Later on, in a friendly match against Egyptian giants Al Ahly, he assisted his side's goal in an entertaining 1–2 loss in front of a large audience.

As soon the 2012–13 season finally kicked off, Mohsen was at loggerheads with the coaching staff and the board due to his persistence on leaving the club to help ensure his spot on the national team.

He was part of Egypt's squad for the 2018 FIFA World Cup in Russia.,[4] playing in all three matches as the team were eliminated in the group stage.