Flores graduated with honors in 1997 with a bachelor's degree in Mass Communication from the College of Arts and Sciences in Loyola University, New Orleans, receiving the Kappa Tau Alpha award for excellence and high Academic standing in Journalism.

[citation needed] From 1997 to 2006, Flores practiced Journalism in her family newspaper, La Tribuna, founded by her grandfather and father December in 1976, following upon a legacy of championing freedom of speech.

She has produced periódicals and magazines in print and online, has served as a columnist for more than a decade, and created a weekly comic strip based on the newspaperboy symbol of the Newspaper called Tribunito, and the Tribuna family.

She also became the youngest and the first woman to hold the position of the First Vice-President of the National Congress of the Republic of Honduras (2006-2010) presiding over Congressional debates and committee meetings, with Government Institutions, International community and civil society.

After returning Honduras to full participation in all regional groups and forums, in 2012 was elected Vice-president of the United Nations General Assembly's 67th Session.