[1] Loveless completed her medical internship at San Francisco General Hospital before setting up a private practice in the city and taking on an assistant role at the Stanford University School of Medicine in the early 1930s.
In 1935, she was recruited by Robert A. Cooke to work in his allergy research laboratory at Roosevelt Hospital in New York, where she studied the treatment of hay fever with pollen extracts.
[1] Loveless turned her attention to insect venom allergies in 1946 when a colleague asked if she knew how to prevent anaphylactic reactions in patients who suffered from hypersensitivity to Hymenoptera bites.
At the time, the clinical standard involved creating extracts made from grinding up the entire body of an insect and administering it in order to desensitize patients.
[1] From 1953 to 1956, she injected patients at her allergy clinic with increasing doses of venom and monitored their reactions to subsequent bee and wasp stings.