Mary MacKillop College, formerly St Joseph's Upper Primary, then St Joseph's High School, is a Catholic girls' secondary school in the Adelaide suburb of Kensington, South Australia.

The Sisters of St Joseph of the Sacred Heart began providing Catholic education in Kensington since 1872.

The order was founded in 1866 by Mary MacKillop, who lived in the Kensington district for eleven years.

[1] The current secondary college was founded in 1944, when 100 students from other schools run by the Josephite sisters were brought together under one roof in Queen Street, Norwood, in a school then named St Joseph's Higher Primary.

Middle school students (Years 7, 8 and 9) study compulsory courses across eight key learning areas.