Her book, Ming-Kwong, City of the Morning Light (1924) became the textbook on China issued by the Central Committee on the United Study of Foreign Missions.

[2] Her father, William Xavier Ninde, was, for a time, president of Garrett Biblical Institute and later Bishop of the Methodist Episcopal Church.

Immediately after her marriage to Francis Dunlap Gamewell (1857–1950) on May 17, 1909, they started for China, there to engage in missionary work.

[5][6] She traveled extensively with him, his role being General Secretary of the China Christian Educational Association, which took him to every part of the country.

For ten years, Gamewell was a member of the National Committee of the Young Women's Christian Association of China.