The state highway also serves to connect the town of Rising Sun (via MD 276) and Interstate 95 (I-95).

MD 222 heads west toward Port Deposit as Bainbridge Road and south as Perryville Road toward an interchange with I-95 (John F. Kennedy Memorial Highway) and the center of Perryville.

MD 275 heads north as Perrylawn Drive, a limited-access two-lane undivided highway.

The highway heads north along a long, sweeping curve that passes to the east of the town limits of Port Deposit.

[1][3] MD 275 is a part of the National Highway System as a principal arterial for its entire length.