Known as Cayots Corner Road, the highway runs 3.96 miles (6.37 km) from MD 213 at Cayots east to the Delaware state line east of St. Augustine in southern Cecil County.

MD 310 reaches its eastern terminus just east of Old Telegraph Road at the Delaware state line.

The highway continues east as Churchtown Road, which leads toward the village of Mount Pleasant.

[5][6] The Maryland State Roads Commission removed an objectionable curve just east of Cayots in 1924.

[8] After US 213 was relocated at Cayots to eliminate the turn in 1951, MD 310 was extended west to its present terminus.