Known for most of its length as West Post Office Road, the state highway runs 2.38 miles (3.83 km) from MD 675 in Princess Anne east to the end of state maintenance east of Princess Anne.

Antioch Avenue continues west two blocks as a municipal street.

The state highway's name changes to West Post Office Road after leaving the town limits of Princess Anne.

West Post Office Road continues east toward Meadow Bridge Road at the boundary between Somerset County and Worcester County just east of the historic post office in the hamlet of West that gives the road its name.

[1][2] Construction of MD 388 as a modern highway began in 1929 and was completed from Princess Anne east to Freetown Road in 1930.