MD 459 begins at the intersection of Columbia Park Road and an exit ramp from eastbound US 50 (John Hansen Highway).

MD 459 turns west and passes through an industrial area as two-lane undivided Tuxedo Road.

Tuxedo Road ends at an intersection with Kenilworth Avenue, which is the old alignment of MD 201, and ramps to and from US 50 west.

[1][2] MD 459 is a part of the National Highway System as an intermodal connector for 0.02 miles (0.032 km) north from its southern terminus.

[10] Construction of the Baltimore and Ohio Railroad's Alexandria Branch overpass of MD 459 and US 50 began in 1958 and was completed in 1959.