Known as Reliance Road, the state highway runs 3.70 miles (5.95 km) from MD 392 at Reliance north to MD 313 near Federalsburg.

The state highway is considered to be in Caroline County for maintenance purposes.

[2] The first section of MD 577 was paved near its northern terminus by 1910 and reconstructed as a state highway in 1935.

The state highway heads northwest as a two-lane undivided road along the Caroline–Dorchester county line, passing through farmland.

The state highway is considered to be in Caroline County for maintenance purposes.