The state highway was constructed from MD 33 to Bozman in the mid-1930s and extended to Neavitt in the late 1950s.

MD 579 heads northwest as a two-lane undivided road through Neavitt, which sits on Balls Creek to the northeast.

The state highway curves north after leaving Neavitt and passes Wells Point Lane, which leads to the Jean Ellen duPont Shehan Audubon Sanctuary.

MD 579 continues north through a mix of farms and residences on large, waterfront lots, curving northeast around the head of Leadenham Creek and into the village of Bozman.

MD 579 heads north out of Bozman, passing through the narrow neck of land between Harris Creek and Broad Creek before reaching the highway's northern terminus at MD 33 (St. Michaels Road) northwest of the town of St.