The depot was a stop on the Southern Pacific Shasta Route until their services here ceased in 1958.

Passenger trains to the city ceased in 1970 when the original California Zephyr was discontinued.

[citation needed] Amtrak's formation in 1971 left Marysville out of the nation's "basic system," but a California Senate Joint Resolution from 1974 requested that the Coast Starlight be rerouted through Sacramento including a stop in Marysville.

[1][5] Amtrak ceased operating at the station by November 1999,[6] as the service was rerouted over the shorter Sacramento Subdivision.

The former Marysville Western Pacific Depot on that line was not reactivated, ending service to the city.