Amtrak's Pacific Surfliner from San Luis Obispo to San Diego, Amtrak's Coast Starlight from Los Angeles to Seattle, Washington, and Metrolink's Ventura County Line from Los Angeles Union Station to East Ventura stop here.

[9] Amtrak service to Van Nuys (the former CalTrain station) began on June 26, 1988, when one San Diegan round trip was extended to Santa Barbara.

[1][13] In January 2018, Metrolink began construction of an island platform — which serves both main tracks — and a pedestrian underpass.

[16] Van Nuys is expected to be expanded in the coming years to provide more connectivity through the Valley and the rest of Los Angeles County.

The Los Angeles County Metropolitan Transportation Authority East San Fernando Valley Light Rail Transit Project line runs adjacent to the station and the agency is planning a stop near Keswick Street to provide an interchange between systems.