Maryville is a village in Madison County, Illinois, United States.

It is bordered to the north by Glen Carbon, to the east by Troy, and to the south by Collinsville.

Illinois Route 159 passes through the village as Center Street, leading north 6 miles (10 km) to Edwardsville, the Madison county seat, and south 4 miles (6 km) to the center of Collinsville.

Interstates 55 and 70 cross the southern end of Maryville together, with access from Exit 15 (IL 159).

On March 8, 2009, 27-year-old Terry Sedlacek shot and killed Senior Pastor Fred Winters in front of the congregation at First Baptist Church of Maryville affiliated with the Southern Baptist Convention.