Maryville Treatment Center is a Missouri Department of Corrections minimum security prison for male inmates on the grounds of the former Mount Alverno motherhouse of the Sisters of St. Francis of Maryville in Polk Township, Nodaway County, just outside Maryville, Missouri.

The center currently provides the 561 offenders housed there with at least six-months of treatment and behavior modification as part of the Offenders Under Treatment (OUT) Program and the Board Substance Abuse Program (BDSAP).

In 1963 they opened the Mount Alverno High School for Girls next to the motherhouse.

In June 1995 Missouri leased the 44 acres (180,000 m2) and the DOC "treatment" began operations on December 3, 1996.

The 525-bed site was due to open later that year as a minimum security prison for nonviolent offenders with substance abuse problems.