Ando has appeared in films such as Takeshi Kitano's Kids Return (1996), Kinji Fukasaku's Battle Royale (2000), Takashi Miike's Sukiyaki Western Django (2007), and Chen Kaige's Forever Enthralled (2008).

When Masanobu Ando completed school his direction towards a specific career path was not immediately concrete.

[3] Ando became a popular young actor in Japan during the late 1990s, but his career slowed down in the 2000s, when he took fewer roles and was only in one or two films per year.

In 1998 he visited Russia to film for a Japanese show, Seinen wa Kouya wo Mezasu, where he travelled from Vladivostok to Khabarovsk along the Trans-Siberian Railway.

[2] Ando co-starred in Takashi Miike's Big Bang Love, Juvenile A with Ryuhei Matsuda.