The central portal flanked by two lion columns has five panels dating from the early 13th century illustrating the legend of Saint Cerbonius.
The interior has a basilica plan with an apse and two aisles, divided by cylindrical columns and cruciform pilasters which end in complex composite capitals.
On the right of the counter-façade is a series of panels in soft stone, dating from the High Middle Ages or, according to some sources, to the 12th-13th century.
At the foot of the altar are two wooden angels from the 15th century, by Domenico di Niccolò dei Cori.
On the right wall is a 15th-century fresco of Saint Cerbonius Accompanied by Ducks, while a Maestà attributed to Duccio di Buoninsegna (1316) can be seen in the chapel to the left of the major one, together with an Annunciation by Raffaello Vanni (17th century).