Rutilio di Lorenzo Manetti (c. 1571 – 22 July 1639) was an Italian painter of late-Mannerism or proto-Baroque, active mainly in Siena.

Among his masterpieces are his contributions to the Casino Mediceo, which he worked alongside Matteo Rosselli, Giovanni Lanfranco, and Cesare Dandini.

He is known for the following works in Siena or nearby towns: Story of St Catherine and Pope Gregory (1597; Palazzo Pubblico), Baptism of Christ (1600; church of San Giovannino in Pantaneto); a fresco cycle of the Story of St Roch (1605–1610; San Rocco alla Lupa), Pope Alexander I freed from prison by an Angel from San Giovanni Battista in Sant'Ansano in Greti; a Temptation of Saint Anthony (1620, Sant'Agostino); a Rest on the Flight to Egypt (San Pietro alle Scale, Siena); a Death of Blessed Antonino Patrizi (Monticiano, 1616), a Blessed Domenico dal Pozzo at the table now in the Certosa of Florence, a Birth of Virgin (1625, Church of Santa Maria dei Servi), and a painting (1628, Church of San Domenico).

He painted a remarkable Allegory of the four seasons and a Parable of the blind men, now in private collections.

Whether this change was mediated by local painters from Siena and Florence, or from direct visits to Rome, is unclear.