[7] There were initially no intermediate stations between the Boston terminal (near Park Square) and Roxbury, as the line passed through the unoccupied Charles River mud flats.

The flats between Tremont Street and the railroad causeway were filled and developed during the 1860s, becoming the west portion of the South End.

[9] In September 1872, the B&P purchased a 6,221 square feet (577.9 m2) parcel at Camden Street from the Boston Water Power Company.

[7] In November 1891, the Old Colony purchased a parcel on the north side of the tracks adjacent to West Chester Park (now Massachusetts Avenue).

[15][24][25] Nearby residents and institutions, including the YCMA on Huntington Avenue, petitioned the railroad in 1912 and 1919 to reopen the station.

[26][27][28] The 1919 petition was opposed by the railroad, which cited low ridership when the station was previously open and a desire not to compete with streetcars.

[31] The entire Orange Line, including Massachusetts Avenue station, was closed from August 19 to September 18, 2022, during maintenance work.