As Route 106 passes south of Lake Mirimichi it enters the town of Foxborough.

The road crosses into Mansfield in Bristol County, where it intersects Route 140 between the two interstates.

It continues eastward, following the Bridgewater town line as intersects the eastern end of Route 104.

It passes through the center of town before intersecting with Route 58 south of the Monponsett Ponds.

Route 106 continues eastward, passing through the northern end of Plympton before entering Kingston.