From Northbridge, Route 122 enters the Worcester suburb of Grafton.

From there, Route 122 turns west, crossing the corner of Millbury (where Exit 96 of the Mass Pike (old exit 11) meets the route) before entering the city of Worcester.

It then passes through the southeastern corner of town before heading towards downtown.

Meanwhile, Route 122 heads northwestward past Moore State Park and into the town of Rutland.

Approximately a mile later, the two routes split shortly after entering Orange.

To celebrate Route 122 North becoming a State Scenic Byway, in October and November 2007, BJ Hill walked the 40-mile (64 km) corridor, beginning in downtown Orange and ending at Worcester State College.