The route passes a strip mall at the southern end of Easthampton's downtown, reaching a junction with Payson Avenue.

At this junction, Route 141 takes over Payson Avenue’s right-of-way as Cottage Street, passing an old factory in Easthampton along with nearby Nashawannuck Pond.

At the junction with Hendrick Street, Route 141 turns south and becomes Mountain Road as it runs along the side of Mount Tom.

Through Smiths Valley, Route 141 runs southeast through a residential neighborhood, reaching a ramp to Interstate 91 southbound (I-91 exit 17).

Crossing through the Oakdale neighborhood in Holyoke, Route 141 eastbound and westbound merge at the junction with Pleasant Street.

After McKinstry Avenue, the route becomes commercial, bending further southeast while passing Aldenville Public Library and crossing under the Mass Pike (I-90).

Route 141 parallels the southern shore of the river, passing numerous residences in the Chicopee Falls neighborhood.

After an intersection with Carew Street, the highway comes in striking distance of the river, entering an interchange with I-291's exit 6 via the American Legion Memorial Bridge.

Entering the Indian Orchard neighborhood, the route stays straight as the Chicopee River turns north.

They believed the contractor had taken out the Manual of Uniform Traffic Control Devices and chosen the Alabama shield.